Immunological and molecular insights into acinar-ductal metaplasia and atypical flat lesions as precursor lesions of pancreatic ductal adenocarcinoma.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC) is known to develop through a stepwise progression from precursor lesions, such as pancreatic intraepithelial neoplasias (PanIN). An alternative carcinogenic pathway has been proposed via transformation of acinar cells, with development of acinar-ductal metaplasia (ADM) and atypical flat lesions (AFL). Defining the characteristics of PDAC precursors is crucial to better understand PDAC carcinogenesis.

Methods

15 KC (Ptf1a^Cre/+, Kras^LSLG12D/+) and 15 KPC-like mice (Ptf1a^Cre/+, Kras^LSLG12D/+, Trp53^LoxP/LoxP, referred as fKPC hereafter) were sacrificed at different time points. A meticulous morphological evaluation was performed to define different lesion types. Multiplex i

SUBMITTER: Yavas A 

PROVIDER: S-EPMC12849142 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature