Oxidative Phosphorylation in Silent Pituitary Adenomas: A Multiomics Perspective.

ABSTRACT: Although the World Health Organization has clearly defined silent pituitary adenomas (SPAs) and functional adenomas (non-SPAs), the detailed biological mechanisms remain unclear. This study conducted a comprehensive analysis of clinical, genomic, transcriptomic, and proteomic differences between SPA and non-SPA. The results revealed significant differences in mutational profiles, with a notably higher mutation rate of the TCHH gene in non-SPA samples. Transcriptomic and proteomic analyses identified distinct expression patterns, highlighting the enrichment of the oxidative phosphorylation pathway and other related Gene Ontology terms in SPA samples. To validate these findings, 11 additional pituitary adenoma samples were analyzed, confirming the critical role of oxidative phosphorylation i

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12849212 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature