Phylogenetic and evolutionary analysis of VP1 coding sequences of foot-and-mouth disease virus serotypes A, O, and SAT2 in Egypt.

ABSTRACT:

Background

Foot-and-mouth disease (FMD) is a highly infectious viral disease caused by the foot-and-mouth disease virus (FMDV), which has seven serotypes requiring serotype-specific vaccines due to the absence of cross-protection. Understanding the genetic evolution of circulating strains is crucial for effective disease control and vaccine design. This study provides the first comprehensive evolutionary analysis of FMDV serotypes A, O, and SAT2 circulating in Egypt (1972-2022), integrating molecular clock modeling and structural analysis to uncover recent viral diversification. This study focused on analyzing the viral protein 1 (VP1) coding sequences from Egyptian field strains of serotypes A, O, and SAT2 using in silico approaches.

Methods

The nucleotide and amino acid se

SUBMITTER: Elrashedy A 

PROVIDER: S-EPMC12849381 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature