Fat's all, folks: culturing and manipulating peri-prostatic adipocytes to probe impacts on prostate cancer biology.

ABSTRACT: Obesity, officially recognised as a global epidemic by the World Health Organization, will soon overtake smoking as the largest preventable risk factor for cancer. By 2035, more than half the world's population is expected to be overweight or obese with a significant increase in obesity-related health expenditures. However, despite the increase in prevalence and the overall lower life expectancy associated with obesity, mechanisms underpinning obesity-driven diseases are not well understood. Adipocytes pose many challenges for in vitro culture due to their poor cell-to-surface attachment and low viability. Their large size and high lipid content can also present methodological challenges for downstream experiments. Several mouse and human-derived primary pre-adipocyte cell lines have been

SUBMITTER: Grunberg N 

PROVIDER: S-EPMC12849434 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature