Rhythm-specific heart rate thresholds during the vulnerable period: integrated analysis for prognostic optimization in heart failure.

ABSTRACT:

Background

Heart rate control during the vulnerable period (1-3 months post-discharge) is critical for improving outcomes in heart failure (HF). Prognostic implications for sinus rhythm (SR) versus atrial fibrillation (AF) patients remain unestablished.

Methods

We conducted an observational study of 438 heart failure patients to evaluate heart rate associations with HF readmission and all-cause mortality, alongside analysis of MIMIC-III database records assessing vulnerable period mortality relationships. This primary investigation was supplemented by systematic review and meta-analysis of cohort studies and randomized trials from PubMed, Embase, and Cochrane Library databases through February 2025 examining heart rate-prognosis correlations during the vulnerable period.

SUBMITTER: Xu M 

PROVIDER: S-EPMC12849439 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature