FOXM1 regulates platelet-induced anoikis resistance in pancreatic cancer cells.

ABSTRACT:

Background

Resistance to anoikis, a form of programmed cell death that occurs after detachment from the surrounding extracellular matrix, is a prerequisite for the survival of circulating tumor cells (CTCs) in the bloodstream. Platelets can interact with these CTCs and protect them from cytokine- and immune cell-mediated cell death. Whether platelets can regulate anoikis resistance by controlling intrinsic gene expression changes in tumor cells that contribute to metastasis has not been studied in detail in pancreatic cancer cells.

Methods

Pancreatic cancer cells were cultured under attached or low-attachment conditions to induce and mimic anoikis. The detached cells were co-cultured with platelets and subsequent gene expression analyses were performed to identify deregulate

SUBMITTER: Ernesti-Soldatkin A 

PROVIDER: S-EPMC12849465 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature