Nationwide whole-genome sequencing reveals local transmission of Mycobacterium tuberculosis in Poland, 2003-2020.

ABSTRACT:

Background

Tuberculosis (TB) remains highly prevalent in many countries and is a significant contributor to infectious disease mortality. Combating TB requires monitoring the global circulation of strains, and analyzing the prevalence of specific strains within populations. Currently, whole-genome sequencing (WGS) enables the precise tracking of TB transmission. Here, we utilized spoligotyping combined with whole-genome sequencing (WGS) to identify cases of M. tuberculosis transmission in Poland. Our study aimed to identify M. tuberculosis clones transmitting in Poland before the beginning of the war in Ukraine and the influx of refugees.

Methods

We used spoligotyping data to identify M. tuberculosis isolates that were possibly transmitted. We used WGS to confirm transmissio

SUBMITTER: Minias A 

PROVIDER: S-EPMC12849491 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature