Diabetes alters the supragingival microbiome through plasma-to-saliva migration of glucose and fructose.

ABSTRACT:

Background

Dental caries, a dysbiotic biofilm disease driven by polymicrobial acidogenesis, often coexists with type 2 diabetes (T2D). Previous studies suggest covarying relationships between circulating and salivary metabolites in patients with T2D. However, the role of hyperglycemia-induced saccharide migration from plasma to saliva in caries pathogenesis remains unclear. Here, we developed a novel method for untargeted metabolomics profiling of trace saliva from sublingual and submandibular glands, comparing this profile with those of plasma and whole saliva in participants with T2D (n = 31) and those with normoglycemia (n = 30). This comparison aimed to determine how circulating saccharide migration into the oral cavity and its subsequent microbial consumption are linked to den

SUBMITTER: Sakanaka A 

PROVIDER: S-EPMC12849494 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature