A phase 1, multicenter, open-label study to evaluate the pharmacokinetics, safety, and tolerability of a single dose of rimegepant in children (aged ≥6 to <12 years) with a history of migraine.

ABSTRACT:

Objective

To evaluate pharmacokinetics (PK), safety, and tolerability of a weight-adjusted dose of rimegepant orally disintegrating tablet (ODT) in children (aged ≥6 to <12 years) with a history of migraine.

Background

Rimegepant 75 mg ODT is approved for acute treatment of migraine (with or without aura) and preventive treatment of episodic migraine in adults. Studies of rimegepant in pediatric populations have not been conducted to date.

Methods

In this phase 1 open-label study, a single dose of rimegepant ODT was administered, based on body weight, to children aged ≥6 to <12 years. Children with body weight ≥15 kg to ≤30 kg received 25 mg (group 1; n = 7), children >30 kg to ≤50 kg received 50 mg (2 × 25 mg; group 2; n = 9), and children >50 kg received 75 mg (grou

SUBMITTER: Lim CN 

PROVIDER: S-EPMC12849519 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature