Polygenic risk score-guided personalized osteoporosis screening: a population-based study.

ABSTRACT:

Background

Despite robust evidence that genetic factors substantially influence both osteoporosis development and fracture risk, current screening guidelines fail to incorporate genetic factors into risk-assessment protocols. This study aims to determine personalized screening ages for osteoporosis based on polygenic risk score (PRS).

Methods

This prospective cohort study utilized data from 223,818 women in the UK Biobank, and only participants who were osteoporosis-free at baseline were included in the study. Participants were categorized into three subgroups (low, medium, and high groups) based on their PRS. Ten-year cumulative risk of osteoporosis, risk-adapted starting age of osteoporosis screening, and risk advancement periods (RAP) of women across different stratificat

SUBMITTER: Wang D 

PROVIDER: S-EPMC12849559 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature