Cell type-specific interactions induce tonic interferon production in endothelial cells in a pathogen-independent manner.

ABSTRACT:

Background

The endothelium promotes a non-adherent vascular surface that facilitates tissue perfusion, prevents clotting, and limits inflammation. Endothelial cells (ECs) execute these tissue-specific functions through the integration of signaling pathways promoted by growth factors, cytokines, extracellular matrix components, and signals from mechanosensory complexes. Furthermore, ECs secrete various molecular signals, leading to the establishment of a specific niche microenvironment. Importantly, ECs can serve as sentinels against invading viral pathogens, propagating anti-viral responses such as the secretion of type I interferons (IFNs). Identification of mechanisms that alter immunity and inflammation at this critical barrier is important to understanding endothelial dysfuncti

SUBMITTER: Surette T 

PROVIDER: S-EPMC12849652 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature