Distinct compositional alterations in plasma lipoproteins in type 2 diabetes: a cross-sectional study of healthy individuals and diabetics with and without cardiovascular comorbidities.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) increases the risk of cardiovascular disease (CVD), largely by alterations in the blood lipids and the metabolism of circulating lipoproteins (LPs). We studied whether the presence of additional risk factors, such as hypertension, or CVD itself, is associated with further alterations in the LP profiles in individuals with T2DM.

Methods

We performed LP profiling using ¹H NMR spectroscopy and quantified 65 parameters in 393 healthy controls (HC) and in 390 T2DM patients with and without cardiovascular comorbidities. Univariate and multivariate analyses were used to assess alterations in LPs in diabetic patients.

Results

Triglycerides in all major LP classes, as well as particle numbers of very low-density lipoprotein

SUBMITTER: Tsay E 

PROVIDER: S-EPMC12849680 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature