Integrin activation by two independently regulated calcium-mediated pathways is required for neutrophil recruitment.

ABSTRACT:

Background

Impaired integrin activation on neutrophils is the hallmark of leukocyte adhesion deficiency syndrome in humans, characterized by reduced leukocyte recruitment. The regulation of intracellular calcium levels in neutrophils is important for cellular processes; however, the exact role of store-operated calcium entry (SOCE) and the involvement of stromal interaction molecule (STIM) calcium sensors, and ORAI1-3 calcium channels in neutrophil activation and recruitment is unknown.

Methods

Using an acute kidney injury (AKI) model, intravital microscopy, and biochemical studies, we examined the molecular mechanisms of Ca²⁺-regulated neutrophil activation and recruitment.

Results

We demonstrate that STIM1 and ORAI1 in neutrophils are selectively required

SUBMITTER: Oguama M 

PROVIDER: S-EPMC12849750 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature