Longitudinal changes in sex hormones in a population of older community dwelling men.

ABSTRACT:

Context

Based on cross-sectional studies and short longitudinal studies, levels of sex hormones (SH) change with age in men. However, there are limited data about SH in men over 80, and few longitudinal studies >10 years.

Objective

The aim of this study was to characterize SH concentrations in older men, and assess long-term changes.

Methods

We studied 477 community dwelling men, ages 78-97 years, who participated in the Osteoporotic Fractures in Men (MrOS) study. Medical history was obtained via clinical visits and questionnaires. Serum sex steroid levels (testosterone, estradiol, estrogen, dihydrotestosterone (DHT)) were assayed using liquid chromatography/mass spectrometry, free testosterone by equilibrium dialysis, and sex hormone binding globulin (SHBG) by radioi

SUBMITTER: Hills ST 

PROVIDER: S-EPMC12849782 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature