Estimates of molecular convergence reveal multiple genes with adaptive variation across teleost fish.

ABSTRACT: Molecular convergence, where specific nonsynonymous changes in protein-coding genes lead to identical amino acid substitutions across multiple lineages, provides strong evidence of adaptive evolution. Detecting this signal across diverse taxa can reveal adaptive variation that may not be apparent when studying individual lineages. In this study, we search for convergent substitutions in the most speciose group of vertebrates, teleost fishes. Using an unsupervised approach, we detected convergence in 89 protein-coding gene families across 143 chromosomal-level genomes. To assess their functional implications, we integrate data on protein properties, gene expression across species and tissues, single-cell RNA sequencing of zebrafish embryonic development, and gene perturbation experiments in

SUBMITTER: Barua A 

PROVIDER: S-EPMC12849823 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature