Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation.

ABSTRACT: Sphingolipids play a crucial role in gut inflammation. Neutral ceramidase (NcDase) serves as a pivotal regulator of ceramide, the central intermediate in sphingolipid metabolism. The contribution of intestinal epithelial cells (IEC) NcDase to colitis is not well understood. Here, a protective mechanism by which IEC NcDase deficiency (Asah2^ΔIEC) and its-related gangliosides prevent dextran sulfate sodium (DSS)-induced colitis in mice is described. Asah2^ΔIEC mice display reduced susceptibility to DSS-induced colitis and increase regulatory T (T_reg) cells compared to Asah2^fl/fl littermates. Deletion of IEC NcDase induces the upregulation of sialyltransferase ST8SIA1 and promotes the sialic-acid-containing ganglioside GD3 production. Siglec-E is a si

SUBMITTER: Xu Z 

PROVIDER: S-EPMC12849859 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature