Designer Solid Self-Emulsifying Nanovaccines Enable Dual Modulation of Dendritic Cells and T Cells for Potent Antitumor Immunity.

ABSTRACT: Peptide-based cancer vaccines offer favorable safety and stability profiles but are limited by rapid clearance and poor immunogenicity. Here, a ≈20 nm solid self-emulsifying (SSE) nanovaccine platform that co-delivers peptide antigens and an oligonucleotide adjuvant containing the 5'-C-phosphate-G-3' (CpG) motif is reported. This formulation elicits T-cell responses 40 fold higher than those of conventional emulsified vaccines and even achieves complete tumor regression at low doses. Apolipoprotein E (ApoE) adsorbed on SSE vaccines enhances lymph node targeting and dendritic cell internalization. Furthermore, SSE is internalized by T cells and promotes lipid raft formation, thereby further sensitizing T cells to activation. These findings reveal a dual mechanism of immune regulation throug

SUBMITTER: Shen X 

PROVIDER: S-EPMC12849924 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature