Systemic Immune Alterations in Paediatric Classical Hodgkin Lymphoma With CCL17 and MCP-4 as Diagnostic and Predictive Biomarkers.

ABSTRACT:

Background

Paediatric classical Hodgkin lymphoma (cHL) is the most common malignancy in adolescents, and despite excellent survival, a subset of patients experiences treatment failure or severe long-term toxicity, underscoring the need for improved risk stratification. Early response assessment is particularly important, as it guides decisions on radiotherapy, where overtreatment can lead to substantial late effects.

Methods

In the context of a large-scale systems-level immunomonitoring initiative, we specifically examined paediatric cHL and profiled their systemic immunology alongside children with intra- and extracranial solid tumours and other lymphomas. Through longitudinal sampling before and after treatment, we aimed to identify diagnostic and prognostic biomarkers rel

SUBMITTER: Hedberg G 

PROVIDER: S-EPMC12849930 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature