Dynamic Regulation of Granular Hydrogels Through Guest-Host Interactions to Spatiotemporally Guide Cellular Migration.

ABSTRACT: Cell migration plays a crucial role in the dynamic processes that guide tissue development, regeneration, and repair; yet, developing cell culture platforms that allow control over cell migration in 3D space and time remains a challenge. Here, a strategy is presented using chemically-responsive granular hydrogels to enable dynamic control over 3D cell migration. Dynamic microgels are fabricated via hyaluronic acid crosslinked via reversible guest-host interactions between adamantane (guest) and β-cyclodextrin (host), which swell in the presence of a cytocompatible competitive guest molecule (adamantane carboxylic acid, Ad-COOH) and de-swell when Ad-COOH is removed. When formed into granular hydrogels, the addition of Ad-COOH results in a dynamic porous material with reduced microgel stiffn

SUBMITTER: Nakamura K 

PROVIDER: S-EPMC12850067 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature