NUSAP1 Recruits DAXX to Suppress HIF-Driven Triple-Negative Breast Cancer Progression.

ABSTRACT: Nucleolar and spindle-associated protein 1 (NUSAP1) is critical for cancer progression. However, its function in cancers is context-dependent, and emerging evidence indicates that NUSAP1 possesses tumor suppressor functions, although the underlying mechanisms remain uncharted. In this study, NUSAP1 depletion is found to significantly increases the proliferation, migration, and invasion of triple-negative breast cancer (TNBC) cells in vitro and promotes TNBC progression in vivo, suggesting that NUSAP1 is a tumor suppressor in TNBC. Mechanistically, NUSAP1 bridges HIFα and the transcriptional repressor death domain-associated protein (DAXX) through its microtubule-associated domain (MAD) to recruit the methyltransferase SETDB1, thereby attenuating HIF transcriptional activity and the express

SUBMITTER: Du Y 

PROVIDER: S-EPMC12850156 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature