Under-Urine-Adhered Supramolecular Hydrogel with Linearly Sustained Quercetin Release Facilitates Hemorrhagic Cystitis Healing via Inflammation Regulation.

ABSTRACT: The clinical management of hemorrhagic cystitis remains challenging because of persistent inflammation and bladder mucosal barrier disruption. Although intravesical therapies, such as quercetin and hyaluronic acid (HA), show potential, their efficacy is limited by rapid urinary clearance. Hydrogels offer potential as sustained-release drug carriers and protective barriers, yet designing adhesive hydrogels with optimal wet tissue adhesion, controlled degradation, and regulation of anti-inflammation remains difficult. Here it is aimed to develop a supramolecular gelatin-based hydrogel adhesive (HADA/gelatin/Ac-β-CD/quercetin, HGCQ) that combines acrylated β-cyclodextrin as a dynamic crosslinker and hydrophobic drug carrier with dopamine-functionalized HA for enhanced tissue adhesion and anti

SUBMITTER: Cao X 

PROVIDER: S-EPMC12850167 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature