A pH-Responsive Biomimetic Antioxidant Nanoplatform with Dual Renal Targeting for Synergistic Therapy of Acute Kidney Injury.

ABSTRACT: Acute kidney injury (AKI) represents a critical clinical condition marked by abrupt deterioration of renal function, primarily driven by oxidative stress, inflammation, and apoptosis. However, effective targeted therapies remain limited. Here, a smart, biomimetic nanoplatform (CeAst@MK) that synergistically addresses oxidative and inflammatory injury in AKI is reported. CeAst nanoparticles are formed via coordination between Ce³⁺ ions and astragalin (Ast), a natural flavonoid with intrinsic ROS-scavenging and anti-inflammatory properties. To enhance immune evasion and renal targeting specificity, CeAst is cloaked with macrophage membranes (MCM) and modified with a kidney-targeting peptide (KTP), yielding the final CeAst@MK system. The platform exhibits pH-responsive release in t

SUBMITTER: Zhang S 

PROVIDER: S-EPMC12850223 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature