Pulmonary-Targeted Nanoparticles Interrupt the Malignant Mechanical and Biochemical Signaling Crosstalk for Idiopathic Pulmonary Fibrosis Therapy.

ABSTRACT: Idiopathic pulmonary fibrosis (IPF) involves transforming growth factor-beta, a key factor that drives biochemical signaling pathways, inducing cellular transdifferentiation and excessive extracellular matrix (ECM) deposition. Increased ECM stiffness alters the mechanical microenvironment of the lung, exacerbating pulmonary dysfunction through mechanical signaling transduction. Here, persistent malignant mechanical and biochemical signaling crosstalk in IPF is demonstrated that drives the relentless progression of the disease. Therefore, inhalable lung-targeted lipid nanoparticles (VB-RT NPs) are developed for co-delivering verteporfin and berbamine to effectively treat IPF by interrupting pulmonary mechanical-biochemical signaling malignant crosstalk. Specifically, VB-RT NPs are modified

SUBMITTER: Li XN 

PROVIDER: S-EPMC12850245 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature