GSK3β-Regulated Lipolysis is Required for Histone Acetylation and Decidualization in Early Pregnancy.

ABSTRACT: Decidualization, a highly programmed differentiation process of the uterine stroma, is characterized by significant biochemical remodeling and is essential for pregnancy. However, the functions and molecular mechanisms of lipid metabolism during decidualization remain poorly understood. In this study, a dynamic process of lipid droplet synthesis and degradation is observed during decidual progression, and GSK3 is identified as a potential regulator for lipolysis. Specifically, lipolysis is inhibited in uterine Gsk3b knockout mice, leading to impaired terminal differentiation of decidual cells. Mechanistically, GSK3β promots phosphorylation-dependent lysosomal degradation of RNF213, which permits the localization of adipose triglyceride lipase (ATGL) on lipid droplets, thereby facilitating

SUBMITTER: Wang P 

PROVIDER: S-EPMC12850330 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature