Identification and Mechanisms of Osteocyte Subsets Involved in the Pathological Progression of Osteoporosis.

ABSTRACT: Osteocytes are the most abundant cell type in bone. However, the detailed functions of osteocyte subsets in osteoporosis have remained obscure. In this study, it is aimed to investigate the impact of osteocyte subset heterogeneity on the pathological process of osteoporosis and new potential molecular mechanisms. Six osteocyte subsets are identified in mouse bones by single-cell sequencing. Among them, the epidermal growth factor receptor (Egfr)+ interleukin-1 receptor type I (Il1r1)+ Semaphorin 5a (Sema5a)+osteocyte subpopulation (bone homeostasis regulatory osteocytes, BHR-Ocys) played a key role in the maintenance of bone homeostasis by regulating osteoblasts and osteoclasts. The data confirm that the increased proportion of BHR-Ocys contributes to bone loss in the postmenopausal osteop

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC12850396 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature