Stromal Cell-Mast Cell Communication Orchestrates Anti-Viral Immunity in the Meninges.

ABSTRACT: Mast cells are tissue-resident immune sentinels. However, their spatial localization and potential role in the antiviral response within the meninges-the protective barrier surrounding the central nervous system-remain unclear. Here, the distribution pattern along meningeal vasculature is maped and identified a post-weaning maturation process. Single-cell RNA sequencing reveals that mast cells mount a robust immune response against LCMV infection. Ablation of mast cells results in reduced CD8⁺ T cell infiltration and impairs viral clearance. Mechanistic dissection identifies a critical role for the IL-33 receptor on mast cells, which responds to IL-33 derived from stromal cells, in mediating antiviral immunity. Further analysis shows that mast cells synergistically upregulate cy

SUBMITTER: Li Q 

PROVIDER: S-EPMC12850450 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature