A systematic review of medication adherence and mortality in chronic disease: Implications for clinical guidelines and policy.

ABSTRACT:

Objectives

This systematic review aims to investigate whether good medication adherence in adults with chronic conditions is associated with a lower mortality risk compared to poor adherence within published literature, and the extent to which this relationship is represented within South African policy and legislation.

Methods

A systematic search of three electronic databases-PubMed, MEDLINE (Ovid) and Scopus-was conducted. Only primary research articles published in English after March 2004 and with study populations >18 years of age were considered. South African health legislation and professional guidelines from 2014 onwards were sourced using search terms aligned with the systematic review strategy and systematically analysed.

Results

Twenty-six articles were in

SUBMITTER: Hamuy Blanco J 

PROVIDER: S-EPMC12850552 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature