Prediction of neutrophil nadir and recovery following paediatric haematopoietic cell transplantation with busulfan conditioning.

ABSTRACT:

Aims

In haematopoietic cell transplantation (HCT), neutropenia resulting from myelosuppression is an expected endpoint following busulfan-based conditioning. However, if prolonged, neutropenia can lead to complications like serious infection and death. The routine use of pharmacokinetic (PK)-guided busulfan dosing has decreased toxicities; however, patients still have serious, sometimes fatal, complications of drug-induced neutropenia. We sought to investigate whether the time-course of neutropenia after HCT could be predicted for paediatric patients following busulfan-based conditioning. Such predictions could guide care, such as timing of infectious prophylaxis and/or growth factor administration.

Methods

This was a single-centre, retrospective study of 146 patients with m

SUBMITTER: Apsel Winger B 

PROVIDER: S-EPMC12850558 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature