Absolute bioavailability and intravenous pharmacokinetics of N-acetyl-D-mannosamine in humans.

ABSTRACT:

Aims

N-acetyl-D-mannosamine monohydrate (ManNAc) is a naturally occurring monosaccharide that has attracted considerable attention for its potential in treating GNE myopathy, a rare autosomal recessive muscle disorder. Despite its promise as an oral treatment, the absolute bioavailability of oral ManNAc has not been determined and there has been no evaluation of the ManNAc pharmacokinetics following intravenous administration in humans. The aim of this study was to investigate the pharmacokinetics of intravenous ManNAc and to characterize its absolute bioavailability following a single oral dose.

Methods

In this single-centre, open-label, crossover study, six healthy adult males were administered ManNAc as a single oral dose (1000 mg) and intravenous dose (100 mg). Blood sam

SUBMITTER: Meola TR 

PROVIDER: S-EPMC12850572 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature