Role of Acid-Sensing Ion Channels 1a in the Regulation of Obesity and the Gut Microbiota.

ABSTRACT:

Objective

Acid-sensing ion channels are proton-activated ion channels predominantly found in the nervous system. They are well known to affect metabolic and neurological health, yet their role in obesity and gut physiology remains unclear. This study investigates how systemic deletion of Asic1a influences obesity, metabolic, and gut-based outcomes.

Methods

Employing male and female rats with systemic Asic1a deletion (Asic1a ^-/-), metabolic, gut, and fecal microbiota (16S rRNA sequencing) measures were assessed following chow diet or high-fat diet administration for 8 weeks. Fecal microbiota transplantation into germ-free mice was carried out as a proof-of-concept approach to assess the gut microbiota's direct impact.

Results

On a chow diet, Asic1a deletion

SUBMITTER: Shearer J 

PROVIDER: S-EPMC12850573 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature