Pulmonary Transit Time Can Be Accurately Quantified From Non-Arterial Input Function Series in First-Pass Cardiac Perfusion MRI.

ABSTRACT:

Purpose

Previous studies suggested that arterial-input-function (AIF) images are necessary to avoid signal saturation for pulmonary transit time (PTT) measurements. This study challenges that notion by investigating whether PTT can be accurately measured using blood pool signals from myocardial enhancement (non-AIF) images during resting first-pass perfusion MRI.

Methods

This retrospective study included 108 patients, 47 scanned using a research radial perfusion sequence, and 61 scanned with a prototype Cartesian quantitative perfusion (qPerf) sequence with inline PTT calculation. An automated pipeline was developed to compute PTT measurements from blood pool signals extracted from both AIF and non-AIF images, as well as from gadolinium concentration curves of the AIF images

SUBMITTER: Zhao M 

PROVIDER: S-EPMC12850576 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature