Dynamic Transitions for Fast Joint Acquisition and Reconstruction of CEST- Rex$$ {R}_{ex} $$ and T1$$ {T}_1 $$.

ABSTRACT:

Purpose

This work proposes a method for the simultaneous estimation of the exchange-dependent relaxation rate Rex$$ {R}_{ex} $$ and the longitudinal relaxation time T1$$ {T}_1 $$ from a single acquisition.

Methods

A novel acquisition scheme was developed that combines CEST saturation with an inversion pulse and a Look-Locker readout to capture the magnetization evolution starting from the inverse transient Z-spectrum. The corresponding signal model, derived from the Bloch-McConnell equations, describes both the transient Z-spectrum and the Look-Locker dynamics. A model-based reconstruction approach is employed to jointly estimate Rex$$ {R}_{ex} $$ and T1$$ {T}_1 $$ . The proposed method was validated using a numerical phantom and benchmarked against conventional CEST and Loo

SUBMITTER: Huemer M 

PROVIDER: S-EPMC12850581 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature