Validation of Intravoxel Incoherent Motion MRI Using Perfused Explanted Human Livers.

ABSTRACT:

Purpose

Evaluate the feasibility of using perfused explanted human livers for validating intravoxel incoherent motion (IVIM).

Methods

Eight (n = 8) explanted livers from deceased donors were obtained. The portal vein and hepatic artery of each explanted liver were connected to a perfusion system. IVIM data were acquired at four total volumetric flow rates (0, 0.6, 0.9, and 1.2 L/min). For each IVIM dataset, diffusion coefficient (D), relaxation-corrected perfusion signal fraction (F_c), blood velocity SD (V_b), and/or pseudo-diffusion coefficient (D*) were estimated. Linear mixed-effects modeling was performed to determine if the effect of applied flow, flow rate, and fibrosis stage on the estimated IVIM parameters was significant (F-tests), while correct

SUBMITTER: Simchick G 

PROVIDER: S-EPMC12850604 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature