Investigation of Endogenous Renal CEST Contrast and the Influence of Respiratory Motion on a Clinical 3 Tesla MRI: An In Vivo and In Vitro Study.

ABSTRACT:

Purpose

The aim is to evaluate the effectiveness of timed breathing in reducing respiratory motion artifacts in renal chemical exchange saturation transfer (CEST) MRI and to assess potential differences in CEST effects between renal compartments.

Methods

An electro-pneumatic phantom with a kidney CEST model simulated variable respiratory motion and sequence-synchronized breathing. Motion-induced deviations from a static reference were quantified using the mean absolute error (MAE). Ten healthy volunteers (six females, four males; 25.2 ± 1.9 years) and one patient (47 years) with ccRCC (3.0 × 2.2 × 2.2) cm³ were examined on a 3 T MRI system using a multi-echo gradient echo sequence with 15 Gaussian-shaped saturation pulses (B₁ = 1.5 μT, t_p = t

SUBMITTER: Gallinnis PJ 

PROVIDER: S-EPMC12850607 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature