Stem Cell Secretome Treatment Reduces Adiposity and Improves Glucose Handling During Obesity and Weight Loss in Mice.

ABSTRACT:

Objective

In this study, we investigated the effects of a stem cell-derived secretome product on adiposity and tissue quality and insulin and glucose levels in obese mice and those undergoing dietary weight loss.

Methods

Following 16 weeks of high fat diet mice received acute (4 weeks) biweekly intramuscular injections with vehicle or secretome while remaining on a high fat diet (HFD vs. HFD-S) or during weight loss upon return to a normal chow diet (HFD/WL vs. HFD/WL-S).

Results

After 4 weeks of treatment, HFD-S mice had greater lean mass (vs HFD), muscle weights, and quadriceps myofibrillar size and improved muscle quality (capillary density and fibrosis). HFD/WL-S mice had accelerated whole-body fat loss and improved glucose handling, fasting insulin levels, and HO

SUBMITTER: Fennel ZJ 

PROVIDER: S-EPMC12850608 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature