Tks4-Targeted Gene Therapy Inhibited White Adipocyte Hypertrophy in Mice.

ABSTRACT: Obesity is one of the most prevalent public health issues worldwide, which substantially increases the risk of many metabolic disorders. Anti-obesity medications and bariatric surgery are clinical treatments for obesity, but suffer from certain limitations. Gene therapy with effective and safe targets provides a novel approach for obesity intervention. Tks4 has been shown to play an essential role in preadipocyte to adipocyte differentiation. However, it is still elusive if it could be a drug target against obesity in vivo. Here, we found the expression levels of Tks4 correlate with adipocyte development and hypertrophy in mice. By generating a Tks4 KO mouse model, we showed Tks4 deletion significantly restricted adipocyte hypertrophy and reduced blood glucose and lipid levels. We further

SUBMITTER: Tian M 

PROVIDER: S-EPMC12850628 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature