Near-Infrared Triggered Anion Transport Induces Cancer Cell Death.

ABSTRACT: Artificial transmembrane anion carriers have shown potential in biological research and medicine, such as chemotherapeutics to treat channelopathies and anticancer agents. Stimuli-responsive systems, controlled by triggers such as light, pH, redox, enzymes, or membrane potential, offer the potential for targeted activation. Photoactivation of ion transport is particularly advantageous due to the possibility of achieving spatiotemporal control, remote addressability, and reduced cytotoxicity. However, poor tissue penetration and undesired cytotoxicity are significant drawbacks to many photo-activated ionophores reported to date, which are mostly triggered by UV or violet light. Here, we report BODIPY-caged photo-responsive anionophores activated with NIR light, which utilize dynamic hydroge

SUBMITTER: Ahmad M 

PROVIDER: S-EPMC12851001 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature