Transscleral photodynamic therapy with a chlorin e6: An experimental study of exposure parameters and therapeutic window.

ABSTRACT:

Purpose

To define optimal exposure parameters and the therapeutic window for transscleral photodynamic therapy (TSPDT) with chlorin e6 by evaluating clinical, histological, and thermal effects of subthreshold, therapeutic, and suprathreshold settings in rabbit eyes.

Methods

The study was conducted on 21 healthy rabbits. TSPDT was performed using a 660 nm laser and chlorin e6 (2.5 mg/kg). Transscleral probes (5 mm: 0.1 W, 0.17 W, 0.3 W; 10 mm: 0.3 W, 0.6 W) with integrated thermosensors were used. Enucleation and histological analysis were performed 14 days post-irradiation.

Results

Fundus examination on day 14 revealed distinct treatment zones correlating with laser settings. The therapeutic window was defined as 0.14-0.17 W (5 mm probe; power density: 0.693-0.866 W/c

SUBMITTER: Boiko EV 

PROVIDER: S-EPMC12851484 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature