Mapping the Undirected Borylation of C(sp³)-H Bonds in Strained Rings.

ABSTRACT: Aliphatic small saturated carbocycles and azacycles are increasingly used as bioisosteres and structural cores in medicinally active compounds due to the beneficial pharmacological and physicochemical properties they can impart. Therefore, a need exists to modify these motifs and to install groups that enable their incorporation into organic structures; these goals can be accomplished by introducing functional groups at the position of the C-H bonds on the rings. However, functionalization of secondary C-H bonds in strained rings, such as cyclopropanes and cyclobutanes, confronts several challenges, including the greater strength of these bonds than those in unstrained rings. Although catalytic, undirected borylation has been reported to functionalize the C-H bonds of selected strained rin

SUBMITTER: La C 

PROVIDER: S-EPMC12851509 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature