Liquid Biopsy Profiling with Multiple Tests in Patients with Metastatic Breast Cancer.

ABSTRACT: The chief goal of the Blood Profiling Atlas in Cancer (BloodPAC) consortium is to promote collaborative efforts that support the development and implementation of liquid biopsy tests. Here, we report the results of a pilot study conducted by three BloodPAC members that aimed to demonstrate a multisite liquid biopsy testing framework using longitudinal blood specimens from 38 patients with metastatic breast cancer. Three laboratories receiving identical samples from two clinical sites each applied a different targeted sequencing platform to analyze mutations in cell-free DNA (cfDNA). The resulting mutational profiles reflected common breast cancer alterations, including clinically actionable mutations for 40% of hormone- receptor-positive patients. In 12 genes with shared target regions acr

SUBMITTER: Higa N 

PROVIDER: S-EPMC12851560 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature