On the effect of reference and sample volume on magnetic particle imaging quantification.

ABSTRACT: Magnetic particle imaging (MPI) is an emerging biomedical imaging modality that enables non-invasive quantification of superparamagnetic iron oxide nanoparticle (SPION) tracers by comparing signal in a region of interest (ROI) to that of reference samples of known tracer mass. However, despite growing interest and use of MPI, recent studies have raised concern over quantification accuracy as a function of the volume over which the tracer is distributed. Here, a constant mass dilution series of the tracer Ferucarbotran contained in well-defined sample geometries was used to evaluate the effect of relative reference and object sample volumes on MPI quantification accuracy. MPI images of this series were acquired under various scan modes, segmented using two commonly used methods, and iron ma

SUBMITTER: Parrett SN 

PROVIDER: S-EPMC12851616 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature