Size tunable fabrication of magnetic alginate microparticles using flow focusing microfluidics.

ABSTRACT: We report the size tunable formulation of magnetic alginate microparticles (MAMs) using a 3D flow-focusing microfluidic device. The droplet phase consisted of iron oxide nanoparticles (IONPs) in an alginate solution and the continuous phase consisted of fluorocarbon oils. We studied the stability of IONP colloids in alginate and calcium ethylenediamine tetraacetic acid solutions using optical microscopy, dynamic light scattering, and zeta potential measurements. These studies suggest that IONPs coated with polyethylene glycol (PEG) were most stable. We then formulated MAMs using the PEG-coated IONP colloid and studied how MAM average size and coefficient of variance varied as a function of droplet and continuous phase flow rates and viscosities. Droplet and MAM size decreased when the carr

SUBMITTER: Rivera-Llabres VG 

PROVIDER: S-EPMC12851618 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature