Patterning of anisotropic physical cues in granular PEG hydrogel composites using magnetic templating.

ABSTRACT: Granular hydrogels represent an important advancement in hydrogel biomaterials for tissue engineering. These granular materials hold advantages over the traditionally formulated hydrogel because the constituent microgels add modularity and a high degree of porosity upon assembly. While granular hydrogels have shown great promise in tissue engineering, their increased porosity is still randomly distributed, unlike the structure of tissues like nerve which possess an anisotropic or hierarchical degree of porosity. We have developed and utilized a technique termed magnetic templating which allows the micropatterning of aligned sacrificial magnetic porogens that can be then removed upon hydrogel crosslinking, leaving an aligned pore architecture. Here we demonstrate the feasibility of magnetic

SUBMITTER: Rivera-Llabres VG 

PROVIDER: S-EPMC12851619 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature