Feasibility and Effectiveness of Liver Transplantation following Immunotherapy in Patients with Hepatocellular Carcinoma.

ABSTRACT:

Introduction

Immunotherapy is an attractive strategy for downstaging/bridging treatment of hepatocellular carcinoma (HCC) before liver transplantation (LT). This multicentre study reports the feasibility and effectiveness of LT following immunotherapy in a French HCC cohort.

Methods

Clinical, biological, and radiological data were collected at the start and end of immunotherapy, and before LT. Outcomes were evaluated through radiological response post-immunotherapy, recurrence risk (R3-alpha-fetoprotein [AFP] score) on explanted livers, and post-LT complications, aiming to assess primary LT success, overall and disease-free survival.

Results

Twenty-one HCC patients (17 males; median age 62 years [57-64]) were included in the study. Fourteen (66.7%) patients were BCLC-

SUBMITTER: Amaddeo G 

PROVIDER: S-EPMC12851629 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature