Bidirectional Mendelian randomization analysis investigating causal associations between 35 blood and urine biomarkers and oral lichen planus.

ABSTRACT: Identification of appropriate biomarkers is of great clinical significance for the early diagnosis of oral lichen planus (OLP). The objective of this study was to comprehensively analyze the association of OLP with blood and urine biomarkers. We analyzed the data of 3,63,228 quality-controlled individuals of European origin from the UK Biobank, using 35 blood and urine biomarkers as the exposure group for this study. For the outcome group, we selected data on OLP from the Finnish database. A 2-sample Mendelian randomization (MR) approach was employed, utilizing single nucleotide polymorphisms (SNPs) associated with the 35 biomarkers as instrumental variables to evaluate the causal relationship between these biomarkers and OLP. The inverse variance weighted (IVW) method was implemented as t

SUBMITTER: Jiang ZH 

PROVIDER: S-EPMC12851668 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature