Mendelian randomization analysis of the causal relationship between low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and androgenic alopecia.

ABSTRACT: Androgenic alopecia (AGA), a common type of hair loss, is linked to various genetic and environmental factors. Dyslipidemia, particularly low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels, has emerged as a potential contributing factor. This study sought to investigate the causal relationship between LDL-C, HDL-C, and AGA using Mendelian randomization (MR). Data were sourced from the Integrative Epidemiology Unit Open Genome-Wide Association Study database. Univariate MR analysis was conducted to investigate the relationships between LDL-C, HDL-C, and AGA. Meanwhile, multivariate Mendelian randomization analysis was further performed to control for the mutual interference between LDL-C and HDL-C, so as to clarify their independent effects o

SUBMITTER: Fu M 

PROVIDER: S-EPMC12851693 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature