Pituitary involvement in ANCA-associated vasculitis: Case report and literature review.

ABSTRACT: The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an rare autoimmune condition characterized by inflammatory cell infiltration causing necrosis of small blood vessels. Pituitary involvement is uncommon in AAV and it can occur at any point during AAV. The main clinical manifestations are central diabetes insipidus and panhypopituitarism. In this article, we describe 2 cases of pituitary involvement of AAV, pituitary dysfunction presented as initial symptom in 1 patient and developed over the course of the diseases in the other patient. Both of them had positive ANCA titers and myeloperoxidase positive antibodies. Two patients both had an enlarged pituitary, shown by magnetic resonance images, 1 patient also had Rathke's cleft cyst. After treatment with intravenou

SUBMITTER: Chen X 

PROVIDER: S-EPMC12851694 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature