Causal association between sarcopenia and iron deficiency anemia: A two-sample Mendelian randomization study.

ABSTRACT: To investigate potential causal links between sarcopenia and iron deficiency anemia (IDA), we conducted a two-sample Mendelian randomization (MR) study using genome-wide association study data. Instrumental variables were selected based on genome-wide significance (P < 5 × 10-⁸), linkage disequilibrium pruning (r2 < 0.001), minor allele frequency > 0.01, and F-statistics > 10. Analysis used inverse-variance weighted method, with MR-Egger, weighted median, and weighted mode for robustness. Sensitivity analyses included Mendelian randomization pleiotropy residual sum and outlier, MR-Egger regression, Cochran Q, and leave-one-out analyses. Genetically predicted faster usual walking pace was associated with a reduced risk of both IDA secondary to chronic blood loss (OR = 0.375, P = .006) and I

SUBMITTER: Li B 

PROVIDER: S-EPMC12851699 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature