The causal effect of scoliosis on mental disorders: A two-sample Mendelian randomization study.

ABSTRACT: Previous studies have investigated the association between scoliosis and mental disorders, but the results have been inconsistent, and the causal relationship remains unclear. In this study, we used two-sample Mendelian randomization (MR) analysis to explore the causal relationship between scoliosis and mental disorders. We conducted a two-sample MR analysis using summary statistics from genome-wide association studies (GWAS) datasets for scoliosis and mental disorders. Various MR methods, including MR-Egger, weighted median, inverse variance weighting (IVW), simple mode, and weighted mode, were employed to assess the potential causal relationship between scoliosis and 7 mental disorders. Subsequently, we conducted further analysis to ascertain potential pleiotropy and heterogeneity. Addit

SUBMITTER: Ren L 

PROVIDER: S-EPMC12851701 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature