Diagnostic utility of cerebrospinal fluid IgG index, 24-hour IgG synthesis rate, and immunophenotyping in primary central nervous system large B-cell lymphoma: A case report.

ABSTRACT:

Rationale

Primary central nervous system (CNS) large B-cell lymphoma (PCNS-LBCL) is a rare and aggressive brain malignancy that is challenging to diagnose early. Conventional imaging methods, such as magnetic resonance imaging and PET-CT, may not provide conclusive results in the early stages. This case highlights the diagnostic utility of cerebrospinal fluid (CSF) IgG index, 24-hour IgG synthesis rate, and immunophenotyping, offering a reliable noninvasive approach to improve early diagnosis when imaging results are inconclusive.

Patient concerns

A 57-year-old male presented with progressively worsening headache, altered consciousness, and cognitive impairment, which developed gradually over several weeks. These symptoms prompted further diagnostic evaluation to identify th

SUBMITTER: Yan Y 

PROVIDER: S-EPMC12851708 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature